Biologics in Rheumatoid Arthritis: Latest Developments and Practical Aspects
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منابع مشابه
Latest developments in the treatment of rheumatoid arthritis : is there new hope for patients ?
Over the past decade, treatment of rheumatoid arthritis (RA) has been revolutionized with the introduction of biological disease-modifying antirheumatic drugs (DMARDs), such as TNF inhibitors (e.g., infliximab, etanercept, adalimumab, golimumab and certolizumab pegol), the IL-6 receptor inhibitor tocilizumab, the chimeric anti-CD20 monoclonal antibody rituximab and the T-cell costimulation inhi...
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Treatment of autoimmune disorders such as psoriasis, rheumatoid arthritis, and Crohn’s disease with so called biologics (selective immunomodulatory drugs) has become a standard way to treat severe or recalcitrant forms of these diseases. In particular, antagonists of tumour necrosis factor (TNF) have been proved to be highly efficacious. In this review we summarise the current knowledge on prob...
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Major achievements have been reached in the treatment of rheumatoid arthritis during past decades due to the recognition of methotrexate as an anchor drug for treatment of rheumatoid arthritis, due to the notion of a treatment window of opportunity in patients with recent-onset rheumatoid arthritis necessitating early aggressive therapy, due to the development of biologics and due to remission ...
متن کاملEffect of additional administration of tacrolimus in patients with rheumatoid arthritis treated with biologics.
OBJECTIVE To explore the effect of additional administration of tacrolimus to rheumatoid arthritis patients treated with biologics, in whom the effect of biologics is unsatisfactory. METHODS Tacrolimus was administered if the effect of biologics was unsatisfactory for 24 weeks at least in terms of laboratory data or DAS28 level: ESR, CRP level and DAS28 level were not below 15 mm/h, 0.2 mg/dl...
متن کاملRheumatoid arthritis, anti-tumour necrosis factor treatment, and risk of squamous cell and basal cell skin cancer: cohort study based on nationwide prospectively recorded data from Sweden
OBJECTIVE To investigate the risk of squamous cell and basal cell skin cancer in patients with rheumatoid arthritis naive to biologic drugs, in patients starting tumour necrosis factor (TNF) inhibitor treatment, and in the general population. DESIGN Population based cohort study. SETTING Nationwide data from Sweden. PARTICIPANTS Cohort of patients with rheumatoid arthritis naive to biolog...
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تاریخ انتشار 2008